Description
The Gold Standard Synergistic Stack for Growth Hormone Research
The CJC-1295 (No DAC) / Ipamorelin Blend is one of the most widely utilized dual-peptide formulations in metabolic and neuroendocrine research. Rather than relying on a single signaling pathway, this blend combines a Growth Hormone-Releasing Hormone (GHRH) analog with a Growth Hormone Secretagogue (GHS) into a single vial.
By targeting two completely different receptors on the pituitary gland simultaneously, these two peptides create a powerful synergistic effect. They trigger a highly amplified, natural release of growth hormone that is significantly stronger than what either peptide could achieve on its own.
Technical Specifications & Composition
This high-purity blend is custom-compounded in an optimal 1:1 milligram ratio (typically available as a 5mg + 5mg or 2mg + 2mg vial) to mirror standard pre-clinical testing protocols:
- CJC-1295 (No DAC) — Modified GRF (1-29): A 29-amino acid peptide that mimics native GHRH, optimized with four amino acid substitutions to resist rapid enzyme breakdown.
- Ipamorelin: A highly selective 5-amino acid pentapeptide that acts as a ghrelin receptor mimic to spark growth hormone release.
- Purity: 99%+ (HPLC and Mass Spectrometry verified).
- Format: Lyophilized sterile white powder.
The Dual-Action Mechanism: How the Synergy Works
When administered together, these two peptides perform a coordinated “double-tap” on the pituitary gland to maximize natural cellular output:
1. Ramping Up the Signal (CJC-1295 No DAC)
CJC-1295 binds directly to GHRH receptors on pituitary cells. This signals the gland to manufacture and release more growth hormone. Because this version contains No DAC (Drug Affinity Complex), it does not artificially force continuous hormone release. Instead, it respects the body’s natural, healthy pulsatile rhythms, staying active in the system for only about 30 minutes.
2. Releasing the Floodgates & Blocking the Brake (Ipamorelin)
Ipamorelin binds directly to the Ghrelin/Growth Hormone Secretagogue receptors. This triggers the immediate release of the growth hormone that the pituitary gland has stored up. Crucially, Ipamorelin also acts to suppress somatostatin—the body’s natural “brake pad” hormone that normally tries to shut growth hormone release down.
Why the 1:1 Blend is Essential
Because Ipamorelin clears the path and removes the brake (somatostatin) while CJC-1295 steps on the gas pedal (stimulating production), the resulting growth hormone pulse is deeply amplified without causing pituitary exhaustion. Furthermore, because Ipamorelin is highly selective, it triggers this release without spiking unwanted side-effect hormones like cortisol (the stress hormone) or prolactin.
Primary Research & Sourcing Applications
- Cellular Tissue Repair & Recovery: Investigated for its ability to accelerate protein synthesis, speed up muscle and connective tissue repair, and support deep injury recovery in animal models.
- Adipose Tissue Metabolism (Fat Loss): Looked at closely in lipid research for its capacity to accelerate lipolysis (the breakdown of stored fat) and improve lean body composition profiles.
- Sleep Architecture & Longevity: Because growth hormone drops heavily with age, this blend is frequently used in longevity models to study deep slow-wave sleep cycles, skin thickness, and cellular vitality.
Storage & Handling
- Long-Term Storage: Keep the sealed lyophilized powder frozen at -20°C or colder to maintain long-term peptide stability. Keep protected from moisture and direct light.
- Reconstitution: Gently mix with Bacteriostatic Water. Because these are delicate amino acid structures, do not shake the vial aggressively after adding liquid—gently swirl until the white powder disk is completely clear.
- Post-Reconstitution Storage: Once mixed, store the liquid solution in a refrigerator between 2°C and 8°C. For optimal accuracy in research data, use the mixed vial within 30 days.
FOR LABORATORY RESEARCH USE ONLY: This compound is strictly intended for in vitro and in vivo laboratory research and neuroendocrine evaluation. It is not approved for human consumption, therapeutic use, or clinical prescription.


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